# Niacin (B3) Feel like you need niacin? Just have [[nutritional yeast]] a single tablespoon has the daily recommended intake. ## Drop #Pasted Vitamin B3, also known as nicotinamide or niacin, has been studied for its potential effects on neutrophils and their function. Several studies have investigated the role of vitamin B3 in modulating neutrophil activity and its impact on various conditions. One study found that vitamin B3 treatment could enhance the killing of Staphylococcus aureus, a bacterium, through a myeloid-specific transcription factor (Paruch et al., 2022). Additionally, vitamin B3 was shown to be efficacious in both prophylactic and therapeutic settings (Paruch et al., 2022). Another study demonstrated that vitamin B3 treatment significantly inhibited neutrophil infiltration into the lungs and elicited a strong anti-inflammatory effect during ventilator-induced lung injury (Chauhan et al., 2020). However, it is important to note that vitamin B3 treatment in this context paradoxically led to the development of significant hypoxemia (Chauhan et al., 2020). Furthermore, vitamin B3 has been reported to reduce neutrophil infiltration into the lungs, thereby reducing inflammation (Chauhan et al., 2020; Kouhpayeh, 2022). This anti-inflammatory effect of vitamin B3 may have implications for conditions involving excessive neutrophil activation and inflammation. It is worth mentioning that vitamin B3 is involved in various cellular processes and has multiple functions beyond its potential effects on neutrophils. It acts as a coenzyme in many reactions and plays a role in cell energy metabolism, redox reactions, and DNA repair (ZHANG et al., 2023; Wu et al., 2022). Vitamin B3 has also been associated with neuroprotection, antioxidant activity, and modulation of inflammatory responses (Wu et al., 2022). While the studies suggest potential benefits of vitamin B3 in modulating neutrophil function and reducing inflammation, it is important to note that the effects of vitamin B3 can be complex and context-dependent. Further research is needed to fully understand the mechanisms and clinical implications of vitamin B3 on neutrophils and immune responses.